The Infona portal uses cookies, i.e. strings of text saved by a browser on the user's device. The portal can access those files and use them to remember the user's data, such as their chosen settings (screen view, interface language, etc.), or their login data. By using the Infona portal the user accepts automatic saving and using this information for portal operation purposes. More information on the subject can be found in the Privacy Policy and Terms of Service. By closing this window the user confirms that they have read the information on cookie usage, and they accept the privacy policy and the way cookies are used by the portal. You can change the cookie settings in your browser.
Isoconazole with an asymmetrical carbon is a broad‐spectrum antimicrobial imidazole, but there is still lack of relevant report about the potential enantioselectivity in biological samples. The object of this research was to develop and validate a sensitive and effective high performance liquid chromatography‐electrospray ionization coupled with tandem mass spectrometry (HPLC‐ESI‐MS/MS) method for...
Limonene‐1,2‐diol is a limonene oxygenated metabolite that possesses eight different stereoisomers, which could result in different biological properties. Nonetheless, the relation between its spatial configuration and biological function is still little explored. The present study aimed to perform the stereoisomers identification using nuclear magnetic resonance (NMR) investigation of the limonene‐1,2‐diol...
Flurbiprofen is clinically effective for the treatment of acute or long‐term rheumatoid arthritis and osteoarthritis. Studies showed that S‐flurbiprofen had better anti‐inflammatory effect than R‐flurbiprofen. As flurbiprofen racemates are usually used in the form of transdermal preparations, such as Flurbiprofen Cataplasms (Zepolas), it is of great significance to investigate the percutaneous permeation...
Chiral separation of β‐blockers is performed by utilizing the supercritical fluid chromatographic method. The chiral columns utilized were Chiralpak IG and Chiralpak IBN‐5. The finest mobile phase was CO2 −0.2% TEA in methanol (60:40). The values atenolol enantiomers retention factors were 6.39 and 8.98. These values for propranolol enantiomers were 3.39 and 4.06. These values for betaxolol enantiomers...
We report herein the synthesis and application of enantiopure C2‐symmetric primary amine‐1,3‐bis‐thiourea organocatalysts in enantioselective conjugate 1,4‐Michael addition of carbonyl containing nucleophiles, to nitroalkenes and N‐phenylmaleimide, leading to final products in good enantioselectivities (up to 99%) and yields (up to 99%). We propose supramolecular noncovalent interactions within the...
Chiral organic pollutants including pharmaceuticals, pesticides, herbicides, flame retardants, and polycyclic musk cause significant risks to both the environment and human health. Chiral pharmaceuticals (CPs) are among the significant class of pseudo‐persistent substances that have been observed in the concentration level from nanomolar to micromolar quantities and cause bad impacts on nontargeted...
The occurrence of racemic and enantiomerically enriched (scalemic) mixtures of secondary metabolites in their natural sources is a rare phenomenon. The unprecedent case of enantiomeric variations from levorotatory to dextrorotatory, and back to levorotatory, passing through an almost racemic mixture, was recently documented for areolal, the major epoxythymol of Piptothrix areolare. In an attempt to...
Stereochemical quality control for pharmaceutical drug substance intermediates is a daunting task, especially considering the need to separate multiple stereoisomers simultaneously with low ppm level sensitivity. To address these challenges, we have successfully implemented chiral column screening, and developed an ultrasensitive liquid chromatography–mass spectrometry (LC‐MS) method to separate four...
The presence of planar chirality of a variety of medium‐sized heterocycles, along with nine‐membered cyclic ketone and its enol ester, was revealed by observation of isolable enantiomers by analytical high‐performance liquid chromatography (HPLC) using a chiral stationary phase with a polysaccharide‐based chiral selector. Several tens of milligrams of enantiomers of the planar‐chiral molecules were...
Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.